Cardiovascular disorder

 

Cardiovascular disorders are the first cause of mortality in western countries, where nearly 40% of the population die of cardiovascular disorders (europe and usa), 25% of which from ischemic cardiopathy.

 

Cardiovascolar disorders follow the formation of ateroschlerotic plaques in arteries, and it etiology (development) depend upon different factors, such as the function of specifi genes within the genotype of the individual, that control blood clotting, blood pressure, colesterol and triglycerids levels, the presence of other pathologies that can be correlated such as diabetes, and finally the lifestyle, age, sex and the environment.

All these factors together determine the risk of developing a cardiovascular disorder, and can differentially influence the health of the individual. the relative incidence of the disease clearly depends the genetic asset of the individual, given that factors such as smoke, eating habits and lifestyle, can be modified.

The risk increases with the age, however, even in the presence of an unfavorable genetic asset, there are factors that can be modified and thus reduce the overall risk of developing a cardiopathy.

 

In order to verify the predisposition to cardiovascular disorders, a specific panel has been develop that focuses on the analysis of genetic polymorhisms around some genes involved in different aspects of cardiopathies.

Blood clotting (PAA-1, fibrinogeno, fattore V Leiden), levels of tryglycerids (ABCA1, APOE, APOA5, APOB, LIPC), arterious pressure (ACE).

This analysis allows to define whether there is an increased risk of developing a cardiovascular disorder (stroke, miocardial infarction, ictus) later in life and adapt our lifestyle to reduce and minize the risks.